As the new mutations of SARS-CoV-2 keep spreading world-wide, significant concerns increasingly worry both citizenship and the institutions. Even if some of these variants are innocuous, others may give the virus a selective advantage. Based on a risk assessment by major authorities involved in the fight against the spread of COVID-19, such as WHO, ECDC, CDC, these mutations are identified as Variants of Concern and monitored, alerting even more globally scientific and medical communities.